Some celebrities have been a real proof of the seven-year itch in a relationship. It could be a sign of boredom or it could be just very human.
Pop queen Madonna, 49, and her film director husband, Guy Ritchie, 39, seem the latest celebrity victims of the dreaded seven-year itch - they were both said to be consulting divorce lawyers this week.
Rumours of a split began circulating at the Cannes Film Festival last month when they were pictured looking miserable together.
A recent scientific study in the States discovered that hundreds of couples - not just celebrities - found cracks starting to show and relations straining after seven years.
So, as we watch another famous match head for meltdown, we take a look at other stars who didn't quite make it to their eighth anniversary.
Jason and Kelly, they were a picture of happiness but it was a shot of Kelly Brook, 28, on a beach with another man that ended her seven-year romance with Lock Stock actor Jason Statham, 35, in 2004. The love rival was Titanic star Billy Zane. He and Kelly are now back together after a short split.
There are Brad Pitt and Jennifer Aniston, Paul Merton and Caroline Quentin, also Reese Witherspoon's and Ryan Philipe. These couples separated after seven years of marriage.
So, why is it seven?
Source: Sunday Mirror